Clinic facilities

Clinical studies support that Charlotte’s Web CBD Clinic™ topicals are safe for massage and frequent use

Leading massage franchise appoints new chief financial officer and vice president of Studies indicate that CBD Clinic™ Hemp Massage Topicals do not irritate or enter the bloodstream after repeated high frequency use, such as in massage therapy

FOR IMMEDIATE RELEASE

DENVER, May 25, 2022 Charlotte’s Web Holdings, Inc. (“Charlotte’s Web”, “CW” or the “Company”), the market leader in full-spectrum hemp-extracted CBD products, today announced results from a series of studies of clinical research on the frequent use of Charlotte’s Web Topicals brand CBD Clinic™ in regular and hot stone massage.

The studies included:

  1. Clinical Safety Testing (CBD Clinic™ Relaxing Massage Cream) – Repeated Insult Patch Test
  2. Clinical Safety Test (CBD Clinic™ Relaxing Massage Cream) – A five-week clinical study on 60 subjects

Research has found that repeated high-frequency use, typical of massage therapists, of Charlotte’s Web CBD Clinic™ massage products did not result in systemic absorption of cannabinoid metabolites into the bloodstream, nor did the products cause skin irritation.

An expert opinion document has been prepared based on the findings of the studies [“Expert Opinion on the Safety Profile of CW Full-Spectrum Hemp Extract in the Practice of Massage Therapy”]. The opinion piece was produced by third-party clinical research organizations, the CW Labs division of Charlottes Web, and a comprehensive literature review. The document was prepared by Dr. Sherry Bradford, Ph.D. Biochemistry. Dr. Bradford is a former faculty member at the University at Buffalo and a member of the editorial board of the Scientific Federation of Oncology and Cancer (Editor-in-Chief) and the Journal of Biomolecular Research and Therapy. In the opinion piece, Dr. Bradford concluded, “Scientific data and research performed on the safety and skin permeation of Charlotte’s Web CBD Clinic™ topical hemp products support safe repeat use by TMs. . [massage therapists]for massage clients, and in normal massage (heat generated by friction only) and hot stone massage (additional heat applied).

Charlotte’s Web, a Certified B Corporation, is committed to building an accountable, science-based, and transparent industry for those seeking access to safe, high-quality hemp-based wellness products. These clinical studies are among the many formal scientific investigations supported by the Company’s CW Labs division.

“These research findings and expert opinion add to the growing body of evidence-based research for topical products from Charlotte’s Web CBD Clinic,” said Tim Orr, President of Charlotte’s Web R&D Division. , CW Labs. “Massage therapists can be sure they’re working with some of the safest, highest quality hemp-based CBD products when they choose CBD Clinic by Charlotte’s Web.”About CBD Clinic™ Topicals

CBD Clinic™ topicals help target different levels of discomfort with high-quality active ingredients naturally derived from menthol and camphor. These cooling and warming counter-irritants divert pain signals from the brain for the temporary relief of minor muscle and joint pain. Plus, they’re made with moisturizing and essential oils like clove oil, eucalyptus oil, jojoba oil, and hemp extract (varies by product). Perfect for sore tendons and tissues that need a little extra care.About CW Labs

Charlotte’s Web Labs (“CW Labs”) is the research and development division of Charlotte’s Web, advancing the science around hemp-derived phytocannabinoids, terpenes and flavonoid compounds. CW Labs is comprised of two centers of excellence: the company’s research and development center located in Louisville, Colorado, with expertise in liquid and gas chromatography, mass spectroscopy, and organic chemistry, and our research center and development in formulation chemistry and clinical research located at the Hauptmann Woodward Research Institute on the campus of the University at Buffalo’s Jacobs School of Medicine and the Center for Integrated Global Biomedical Sciences, and is part of the State University network of New York (SUNY). Research funding and product support is provided by the CW Labs division of Charlotte’s Web Inc. About Charlotte’s Web Holdings, Inc.

Charlotte’s Web Holdings, Inc., a Certified B Corporation headquartered in Denver, is the market leader in innovative hemp extract-based wellness products under a family of brands that includes Charlotte’s Web™, CBD Medic™, CBD Clinic™ and Harmony Hemp™. Charlotte’s Web brand premium products begin with proprietary hemp genetics that are 100% grown in the USA using organic and regenerative growing practices. The Company’s hemp extracts contain natural botanicals, including cannabidiol (“CBD”), CBC, CBG, terpenes, flavonoids and other beneficial compounds. The company’s CW Labs R&D division advances hemp science at two centers of excellence in Louisville, Colorado, and the University at Buffalo’s Hauptmann Woodward Research Institute, part of the University of New York State (SUNY). Web Product Categories Include Full Spectrum Hemp CBD oil tinctures (liquid products), CBD gummies (sleep, stress, exercise recovery)CBD capsules, Topical CBD creams and lotionsas good as CBD Pet Products for Dogs. Through its vertically integrated business model, Charlotte’s Web maintains strict control over product quality and consistency with over 20 product batch tests for quality assurance. Charlotte’s Web products are distributed to over 15,000 retailers, over 8,000 healthcare professionals and online through the company’s website at www.CharlottesWeb.com. Charlotte’s Web’s mission is to “unleash the healing powers of plants with compassion and science, for the benefit of the planet and all who live on it”.Forward-looking information

Certain information contained in this press release constitutes forward-looking statements and forward-looking information within the meaning of applicable securities laws (collectively, “Forward-Looking Information”). In some, but not necessarily all, cases, forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “target”, “expects” or “does not expect”. to”, “is expected”, “an opportunity exists”, “is positioned”, “estimates”, “intends”, “assumes”, “anticipates” or “does not anticipate” or “believes”, or variations of these words and phrases or states that certain actions, events or results “could”, “may”, “will”, “could”, “will” or “will be undertaken”, “will occur” or “will be carried out “. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances contain forward-looking information. Specifically, this press release contains forward-looking information relating to, among other things, the future of Charlotte’s Web and the impacts of management changes.

Statements containing forward-looking information are not historical facts, but rather represent management’s current expectations, estimates and projections regarding the future of our business, future plans, strategies, projections, expected events and trends, the economy and other future conditions. Forward-looking information is necessarily based on a number of opinions, assumptions and estimates which, although considered reasonable by the Company as of the date of this press release, are subject to risks, uncertainties, assumptions and other known and unknown factors that may cause actual results, level of activity, performance or achievements to differ materially from those expressed or implied by such forward-looking information. Important factors and assumptions used in developing the forward-looking information contained herein include, but are not limited to, the following: the impact of the COVID-19 pandemic; the regulatory climate in which the Company currently operates and may operate in the future; consumer interest in CBD; successful sales of the Company’s products; and the success of sales and marketing activities. Important factors that could cause actual results and financial condition to differ materially from those set forth in the forward-looking information include, among others, the factors discussed in the “Risk Factors” section of the Company’s most recent annual report filed on Form 10-K. for the year ended December 31, 2021 available at www.SEDAR.com and www.sec.gov and other risk factors contained in other documents filed with the Securities and Exchange Commission available at www.sec.gov and filings with Canadian securities regulators available at www.sedar.com. Except as required by applicable securities laws, the Company undertakes no obligation to update publicly any forward-looking information, whether written or oral, which may be made from time to time, whether as a result of new information, future developments or otherwise.

SOURCE Charlotte’s Web Holdings, Inc.

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